Djokovic beats Cilic in Tel Aviv to claim third title of the season
The 35-year-old Djokovic triumphed 6-3, 6-4 to add the Israeli trophy to victories in Rome and Wimbledon this season.
It was Djokovic's 19th win over Cilic in 21 meetings in a rivalry stretching back to 2008.
Djokovic was playing his first singles tournament since wrapping up a seventh Wimbledon crown and 21st Grand Slam title in July.
He was banned from the US Open and the entire North American hard court swing over his refusal to be vaccinated before returning for Roger Federer's farewell in the Laver Cup team event in London last month.
On Sunday, Djokovic broke Cilic in the second game of the final and pocketed the first set with a fourth ace after 47 minutes on court.
Former US Open winner Cilic, chasing a 21st career title but first of 2022, was broken in the first game of the second set and the 34-year-old never recovered.
The Serb only faced one break point in the final which was clinched in 94 minutes.
Djokovic, who didn't drop a set all week, now heads to the Astana ATP tournament where world number one Carlos Alcaraz takes the top seeding.