US Open clash with Serena a dream come true for Tomljanovic
Tomljanovic beat Russia's Evgeniya Rodina (33) on Wednesday just minutes before Williams, who is expected to retire after the tournament, upset world number two Anett Kontaveit (26) to advance to the third round.
"It's definitely something I'll never forget in my career," Tomljanovic told reporters after her 1-6 6-2 7-5 win.
"It's going to be a huge moment no matter the outcome. I've been a Serena fan since I was a kid. On Friday night I'll just be a competitor and I'll try my best to win."
The Australian said the 23-time Grand Slam champion's impact reverberates well beyond the tennis court.
"I think she's changed the sport of tennis, but also what she's done worldwide for women in sports is incredible," she said.
"She's paved the way for so many, inspired me to go for my dreams. Even her longevity. I'm kind of in the part of my career now where they call you on the older side. She's made that kind of nonexistent. 'Old' is not even a word in her vocabulary. Very grateful to her like that.
"I don't think there's anyone like her, obviously."
Williams said she has been impressed with what she has seen from Tomljanovic, who has reached the quarter-finals of Wimbledon the past two years in her best results at a Grand Slam tournament.
"She's been playing pretty intense and I've been actually watching her matches a lot," Williams said.
"She's been through a lot of injuries, so I kind of respect that. I think it's going to be a good match."
One challenge for Tomljanovic will be finding a way to not let the Serena-supporting crowd get under her skin as the Estonian Kontaveit admitted it did during her match with Williams on Wednesday.
"When the crowd gets involved, that's what it can get to you," Tomljanovic said.
"I just need to stay within my little bubble, have my corner that I go to when I need help just for support, block it out as much as I can."